Drinking More Water May Help Lower Fat Percentage


A high sugar diet has been shown to have a strong connection with metabolic syndrome (a combination of diabetes, high blood pressure and obesity). This syndrome increases the chances of an individual developing coronary heart disease, stroke, and conditions which may negatively affect the blood vessels. Therefore, a reduction in how much sugar is ingested may be very important in improving metabolic syndrome. Additionally, a correlation between the levels of vasopressin (an anti-diuretic hormone which helps in maintaining osmolality and consequently extracellular fluid) and those with metabolic syndrome of similar conditions has been identified.

Elevated levels of vasopressin may increase the likelihood of obesity and diabetes. Increased levels of fructose (a form of sugar) has also shown to increase vasopressin levels. It has been shown that increasing hydration levels helps in combating this syndrome. However, the role of vasopressin in metabolic syndrome caused by sugar is not clearly understood. Therefore, researchers at the University of Colorado tested the hypothesis that ‘vasopressin is a mediator of fructose-induced obesity and diabetes’. They did this by feeding mice fructose water, measuring vasopressin levels, and observing physiological aspects which, may contribute to the development metabolic syndrome.

A graphical illustration of the effects of an increased water intake on metabolic syndrome.
Source: Andres-Hernando et al. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. 

This study showed that vasopressin has a role outside of osmolality and conserving extracellular fluid. This hormone also has a role in elevating the production levels of fat. It has been previously proven that animals with high levels of fat have decreased levels of water availability. In addition, vasopressin may also reduce the loss of water by a different mechanism, acting as a survival hormone which ‘stimulates fat accumulation as a means of preserving and storing energy and water’. The researchers also observed that the metabolism of fructose increases the levels of vasopressin as metabolic syndrome is developing. Arguably the most important discovery, the researchers observed that increasing water intake in the mice prevented and treated metabolic syndrome caused by fructose. This increase in water showed lower levels of fructose, body weight, fatty liver, fat mass and percentage and more.

They also identified that V1bR (a vasopressin receptor) is crucial in the development of metabolic syndrome caused by fructose. This allowed the researchers to determine the mechanism by which vasopressin may actually stimulate the development of metabolic syndrome. They noticed that this receptor actually aided in the development of this syndrome by the fructose enzyme fructokinase which metabolises fructose.

Clinically this study may encourage those who have high sugar diets to increase their water intake. This may be one step in reducing the probability of developing metabolic syndrome. It is very important however to remember that most of this experiment was carried out in mice. Therefore, more research is required to identify the role of vasopressin in metabolic syndrome in humans, which may prove important for therapeutic interventions.

This study displayed that an increase in water intake may actually be of great help in reducing our body fat and therefore our body weight and sugar levels. This is important in decreasing the chances of developing diseases, such as metabolic syndrome.

What do you think about this? Have you ever seen that an increase in your water intake has positively affected your weight? Let us know in the comments below!

Featured Image : by Julia Zolotova, Pexels.

Original Source : Andres-Hernando A, Jensen T, Kuwabara M, Orlicky D, Cicerchi C, Li N et al. Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor. JCI Insight.

Edited by Cyrus Rohani-Shukla

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